能量代谢调控研究组 —— 代表论著
第一作者论文
- Jin W# ，Goldfine A，Boes T，Henry R，Ciaraldi T， Kim EY，Emecan M， Fitzpatrick C，Sen A， Shah A， Mun E，Vokes V， Schroeder J， Tatro E，Jimenez-Chillaron J， Patti ME*，Increased SRF transcriptional activity is a novel signature of insulin resistance in humans and mice，J Clin Invest，2011, 121(3):918-929
- Jin W# ，Patti ME*，Genetic determinants and molecular pathways in the pathogenesis of diabetes, Clin Sci, 2009, 116(2):99-111
- Jin W# ，Takagi T， Kanesashi S， Kurahashi T，Nomura T，Harada J，Ishii S*， Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins，Developmental Cell，2006,10(4);461-471
通讯作者论文
- Linhu Quan#, Chuanhai Zhang#, Meng Dong#, Jun Jiang#, Hongde Xu#, chunlong Yan#, Xiaomeng liu, Huiqiao Zhou, Hanlin Zhang, Li Chen,Fei liang Zhong, Zhaobo luo, Sin Man lam, Guanghou Shui, Donghao li*, Wanzhu Jin*.Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. 2019; 0:1–9.
- Na Yin #, Hanlin Zhang,Rongcai Ye, Meng Dong,Jun Lin,Huiqiao Zhou,Yuanyuan Huang,Li Chen,Xiaoxiao Jiang,Kentaro Nagaoka , Chuanhai Zhang*,and Wanzhu Jin*. Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. Int J Mol Sci. 2019 Apr 1,20(7). pii: E1622.
- Zheng Q#, Lin J#, Huang J#, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y*, Jin W*, Zhao J*. Reconstitution of UCP1 Using CRISPR/Cas9 in the White Adipose Tissue of Pigs Decreases Fat Deposition and Improves Thermogenic Capacity. PNAS.2017,114(45): E9474-E9482.
- Hu T#, Yuan X, Wei G, Luo H*,Lee HJ*, Jin W*.Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice. Eur J Nutr. 2018.57(1):391-403.
- Yilin You#, Xiaoxue Yuan#, Xiaomeng Liu#, Chen Liang, Minghui Meng, Yuanyuan Huang, Xue Han, Jielong Guo, Yu Guo, Chenglong Ren, Qianwen Zhang, Xiangyu Sun,Tingting Ma, Guojie Liu, Wanzhu Jin*,Weidong Huang*and Jicheng Zhan*.Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function .Mol Nutr& Food Res.2017.61(11): 1-13.
- Hu T#, Yuan X#, Ye R #, Zhou H, Jun Lin, Zhang C, Hanlin Zhang, Wei G, Meng Dong, Huang Y, Lim W, Liu Q, Lee H, Jin W*. Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. JNB.2017.47:21-28.
- Rong Wu#, Xiao-meng Liu, Jian-guang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Ji-qiu Wang, Jian-qing Ding, Dong-hao Li , John R Speakman, Guang Ning, Wanzhu Jin*, Zengqiang Yuan*. DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue. Cell Discovery (2017) 3, 16054:1-18.
- Lin J#, Cao C#, Tao C#, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C,Li K,Speakman J,Wang Y*,Jin W*,Zhao J*. Cold adaptation in pigs depends on UCP 3 in beige adipocytes. JMCB. 2017. 9(5):364-375.
- Yuan X#, Wei G#, You Y#, Huang Y, Lee H, Dong M, Lin J, Hu T, Zhang H, Zhang C, Zhou H, Ye R, Qi X, Zhai B, Huang W, Liu S, Xie W, Liu Q, Liu X, Cui C, Li D, Zhan J, Cheng J, Yuan Z, Jin W*. Rutin ameliorates obesity through brown fat activation. the Faseb journal .2017. 31(1):333-345.
- Wu R#, Sun JG, Wang JQ, Li B, Liu Q, Ning G, Jin W*, Yuan Z*. c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice. Diabetologia. 2017. 60(5):900-910.
- Zhang C#, Weng Y, Shi F, Jin W*.The Engrailed-1 Gene Stimulates Brown Adipogenesis .Stem Cells Int. 2016:7369491.
- Xiaoxue Yuan#, Tao Hu#, Han Zhao#, Yuanyuan Huang, Rongcai Ye, Jun Lin, Chuanhai Zhang, Hanlin Zhang, Gang wei, Huiqiao Zhou, Meng Dong , Jun Zhao, Haibin Wang, Qingsong Liu , Hyuek-Jong Lee, Wanzhu Jin* and Zi-Jiang Chen*. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.PNAS.2016,113(10): 2708–2713.
- Liu X#, Wang S#, You Y#, Meng M, Zheng Z, Dong M, Lin J, Zhao Q, Zhang C, Yuan X, Hu T, Liu L, Huang Y, Zhang L, Wang D, Zhan J, Hyuek Jong Lee, Speakman J, Jin W*. Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice. Endocrinology, 2015, 156 (7): 2461-2469.
- Yanyan Shen#,Xiaomeng Liu, Meng Dong ,Jun Lin,Qianwei Zhao,HyuekJong Lee,Wanzhu Jin*. Recent advances in brown adipose tissue biology. Chin. Sci. Bull. 2014,59(31):4030–4040.
- Liu X#, Zheng Z, Zhu X, Meng M, Li L, Shen Y, Chi Q, Wang D, Zhang Z, Li C, Li Y, Xue Y, Speakman J and Jin W*. Brown adipose tissue transplantation improves whole-body energy metabolism. Cell Research, 2013, 23(6): 851-854.
获得专利：
- Patti ME，Wanzhu Jin，Goldfine A，Inhibiting Serun Response Factor (SRF) to Improve Glycemic Control，2009.6，美国，US8003606
- Patti ME，Wanzhu Jin，Goldfine A，Inhibiting Striated Muscle Activator of Rho Signaling (STARS)，2011.6，国际，PCT/US2011/039059